Technology




Biomechanical Mapping of the Female Pelvic Floor


This technology was advanced in cooperation with Artann Laboratories within the scope of the NIA/NIH grants (Phases I-IV).

Biomechanics of the Female Pelvic Floor

Definitions

Tactile Imaging is a medical imaging modality translating the sense of touch into a digital image. The tactile image is a function of P(x,y,z), where P is the pressure on soft tissue surface under applied deformation and x,y,z are coordinates where pressure P was measured. The tactile image is a pressure map on which the direction of tissue deformation must be specified [OJOG].

Functional Tactile Imaging translates muscle activity into dynamic pressure pattern P(x,y,t) for an area of interest, where t is time and x,y are coordinates where pressure P was measured.
It may include [Biomechanics]:
  1. muscle voluntary contraction,
  2. involuntary reflex contraction,
  3. involuntary relaxation,
  4. specific maneuvers.
Biomechanical Mapping = Tactile Imaging + Functional Tactile Imaging [EC Gynaecology]

Clinical Applications

Many of tissue or organ disorders and diseased conditions are significantly manifested in changes of their mechanical properties such as soft tissue elasticity, structure support, muscle mobility and contractile strength. Therefore, the biomechanical mapping of a human organ or tissues of interest opens new possibilities in medical imaging, diagnostic, targeted treatment and monitoring.

Specifically, this technology is applicable for detection and characterization of the diseased conditions in the female pelvic floor (prolapse, incontinence, chronic pelvic pain), pathologies (endometriosis, adenomyosis and uterine fibroids, cervical and ovarian cancer), spontaneous preterm delivery and maternal birth trauma.

We are working to introduce a new integral parameter - Biomechanical Integrity score (BI-score) - to allow a comprehensive biomechanical characterization of the pelvic floor. Objectively measurable transformations of pelvic tissues, support structures, and functions under different diseased conditions may be studied with the BI-score.

Figure 1. BI-Score and its components for a 58 y.o. patient acquired with the VTI.

Patents

    Issued
  1. Methods and probes for vaginal tactile and electromyographic imaging and location-guided female pelvic floor therapy. No. 9,861,316; January, 2018.
  2. Method and device for measuring tactile profile of vagina. No. 8,840,571; February, 2014.
  3. Methods for assessment of improvements in pelvic organ conditions after an interventional procedure. No. 8,419,659; November, 2013.
  4. Methods for assessment of pelvic organ conditions affecting the vagina. No. 8,187,208; May, 2012.
  5. Method of characterization and differentiation of tissue. No. 8,142,368; March, 2012.
  6. Tactile sensor array for soft tissue elasticity imaging. No. 8,069,735; December, 2011.
  7. Methods for characterizing vaginal tissue elasticity. No. 8,052,622; November, 2011.

  8. Pending
  9. Method for characterization of the female pelvic floor with a biomechanical integrity score. No.17,526,271; November, 2021.
  10. Methods for vaginal tactile and ultrasound image fusion. No. 17,028,636; September, 2020.
  11. Method and probe for predicting spontaneous preterm delivery. No. 16,574,270; September, 2019.
  12. Methods for biomechanical mapping of the female pelvic floor. No. 16,055,265; August, 2018.

©2022 Advanced Tactile Imaging, Inc.